| with the exception of caffeine | 6 | other |
| from the renewable starting materials caffeine | 6 | other |
| from cinchonine | 3 | other |
| ligand → be → prepared | 15 |
| ligand → be → added | 11 |
| ligand → be → modified | 5 |
| ligand → be → designed | 4 |
| negative | neutral | positive |
| 0.059 | 0.807 | 0.134 |
| Raw frequency | 35 |
| Normalized frequency | 0.597 |
| Modifier score | 1.000 |
| Perplexity | 376.220 |