| particularly | 6 | degree |
| due to increased opioid tolerance at baseline | 2 | cause |
| like many people | 2 | other |
| patient → be → difficult | 13 |
| patient → be difficult to → manage | 3 |
| negative | neutral | positive |
| 0.585 | 0.367 | 0.048 |
| Raw frequency | 16 |
| Normalized frequency | 0.335 |
| Modifier score | 0.475 |
| Perplexity | 88.405 |