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estrogen → ReceivesAction → produced by ovary	0.71
estrogen → IsA → hormone	0.68
effect (aspect of estrogen) → ReceivesAction → examined	0.68
role (aspect of estrogen) → ReceivesAction → understood	0.68
estrogen → HasProperty → low	0.60
synthetic estrogen (subgroup of estrogen) → ReceivesAction → shown to be harmful	0.59
estrogen → HasProperty → essential	0.58
estrogen → CapableOf → increase the risk	0.57
estrogen → ReceivesAction → produced by the body	0.57
estrogen → HasProperty → neuroprotective	0.56
estrogen → CapableOf → protect bone	0.55
estrogen → HasProperty → high	0.55
estrogen → ReceivesAction → produced	0.51
estrogen → HasProperty → effective	0.51
estrogen → ReceivesAction → associated with woman	0.51
estrogen → HasProperty → harmful	0.50
estrogen → ReceivesAction → produced by adrenal glands	0.50
estrogen → HasA → positive effects	0.49
effect (aspect of estrogen) → HasProperty → unknown	0.49
estrogen → HasA → effect	0.48
estrogen → CapableOf → refer to the female hormones estradiol	0.48
estrogen → HasA → protective effect	0.47
estrogen → IsA → important hormone	0.46
estrogen → CapableOf → prevent heart disease	0.45
estrogen → ReceivesAction → secreted by female	0.45
estrogen → CapableOf → cause cancer	0.45
estrogen → CapableOf → circulate in the body	0.45
estrogen → CapableOf → increase breast cancer risk	0.44
estrogen → ReceivesAction → used in combination	0.44
estrogen → AtLocation → woman	0.44
estrogen → CapableOf → bind to receptor	0.44
estrogen → CapableOf → prevent osteoporosis	0.43
estrogen → ReceivesAction → combined with progesterone	0.42
effect (aspect of estrogen) → ReceivesAction → seen in athlete	0.42
effect (aspect of estrogen) → HasProperty → beneficial	0.42
estrogen → IsA → dominant hormone	0.42
estrogen → CapableOf → refer to estrone	0.42
estrogen → CapableOf → prevent bone loss	0.42
estrogen → AtLocation → man	0.42
estrogen → CapableOf → work in the body	0.42
estrogen → ReceivesAction → applied to the skin	0.41
estrogen → ReceivesAction → produced by conversion of androstenedione	0.41
estrogen → ReceivesAction → metabolized	0.41
estrogen → HasProperty → dominant	0.41
estrogen → CapableOf → increase bone density	0.41
effect (aspect of estrogen) → HasProperty → slight	0.40
effect (aspect of estrogen) → CapableOf → occur	0.40
estrogen → CapableOf → cause	0.40
estrogen → CapableOf → promote cell growth	0.39
estrogen → IsA → a steroid hormone	0.39
estrogen → ReceivesAction → produced in fat tissue	0.39
estrogen → ReceivesAction → broken down in the liver	0.38
estrogen → CapableOf → refer to estriol	0.38
estrogen → HasA → same effect	0.38
estrogen → CapableOf → protect woman	0.38
effect (aspect of estrogen) → HasProperty → dependent	0.38
role (aspect of estrogen) → HasProperty → controversial	0.38
estrogen → ReceivesAction → produced by the placenta	0.37
estrogen → CapableOf → prefer the progression of lupus	0.37
estrogen → CapableOf → affect memory	0.36
estrogen → HasProperty → inflammatory	0.36
estrogen → IsA → two hormones	0.36
estrogen → CapableOf → provide strength	0.36
estrogen → ReceivesAction → used in hrt	0.35
estrogen → Causes → weight gain	0.34
estrogen → ReceivesAction → released	0.34
estrogen → CapableOf → regulate menstrual cycle	0.34
estrogen → HasProperty → safe	0.34
estrogen → ReceivesAction → discontinued	0.34
pomegranate → HasA → estrogen	0.34
effect (aspect of estrogen) → HasProperty → harmful	0.33
estrogen → ReceivesAction → reabsorbed	0.33
estrogen → CapableOf → protect the brain	0.33
estrogen → CapableOf → affect blood vessels	0.33
estrogen → CapableOf → exert effect	0.33
estrogen → IsA → a growth hormone	0.33
estrogen → CapableOf → reduce the risk of fractures	0.33
estrogen → HasA → many important functions	0.33
estrogen → CapableOf → accelerate cutaneous wound healing	0.33
estrogen → ReceivesAction → tapered	0.33
estrogen → CapableOf → increase the risk of stroke	0.32
effect (aspect of estrogen) → HasProperty → substantial	0.32
effect (aspect of estrogen) → HasProperty → maximal	0.32
effect (aspect of estrogen) → ReceivesAction → caused by the use of anabolic steroids	0.32
estrogen → Causes → fluid retention	0.31
estrogen → ReceivesAction → detoxified through same p450 enzymatic pathway	0.31
estrogen → CapableOf → protect against stroke	0.31
estrogen → CapableOf → give their distinct sexual characteristics	0.31
estrogen → ReceivesAction → balanced by progesterone	0.31
estrogen → ReceivesAction → added	0.31
birth control → HasA → estrogen	0.30
estrogen → HasSubevent → more fat	0.29
estrogen → AtLocation → cosmetic	0.29
effect (aspect of estrogen) → CapableOf → counteract etrogenic side effects	0.29
estrogen → ReceivesAction → stored	0.28
estrogen → CapableOf → enter circulatory system	0.28
estrogen → CapableOf → promote vascular lesions	0.28
estrogen → ReceivesAction → taken as pill	0.28
estrogen → CapableOf → reduce hot flashes	0.28
estrogen → ReceivesAction → absorbed through the skin	0.28
estrogen → ReceivesAction → shown to inhibit cyp1a2-mediated caffeine metabolism	0.28
estrogen → ReceivesAction → contained in oral contraceptives	0.28
estrogen → CapableOf → promote survival	0.28
estrogen → Causes → mood swings	0.27
estrogen → HasSubevent → diminished	0.27
estrogen → HasSubevent → extra fat storage	0.27
estrogen → CapableOf → protect the heart	0.27
effect (aspect of estrogen) → ReceivesAction → associated with the compound	0.26
estrogen → AtLocation → birth control pills	0.25
estrogen → HasProperty → absent	0.25
estrogen → CapableOf → reduce a woman’s ability	0.25
medicine → HasA → estrogen	0.25
estrogen → ReceivesAction → made in muscle	0.25
estrogen → CapableOf → raise hdl	0.25
estrogen → ReceivesAction → started after menopause	0.25
estrogen → CapableOf → signal through erα	0.25
estrogen → ReceivesAction → produced for first 10-12 days	0.25
estrogen → HasProperty → undetectable	0.25
estrogen → ReceivesAction → contraindicated	0.25
estrogen → CapableOf → enhance the production of evl	0.25
estrogen → ReceivesAction → responsible for sexual development	0.25
estrogen → CapableOf → regulate cardiovascular health	0.25
estrogen → CapableOf → maintain skin moisture	0.25
estrogen → CapableOf → effect hdl goodcholesterol values	0.25
estrogen → CapableOf → bypass digestive tract	0.25
estrogen → CapableOf → decrease osteoblast apoptosis	0.25
estrogen → CapableOf → protect against gastric cancer	0.25
estrogen → CapableOf → run the show	0.25
circulating estrogen (subgroup of estrogen) → CapableOf → exist in dynamic equilibrium of metabolic interconversions	0.25
effect (aspect of estrogen) → HasProperty → mild	0.25
effect (aspect of estrogen) → HasProperty → greater	0.25
effect (aspect of estrogen) → HasProperty → specific	0.25
role (aspect of estrogen) → ReceivesAction → studied	0.25
estrogen → CapableOf → become carcinogenic	0.24
estrogen → CapableOf → increase insulin sensitivity	0.24
estrogen → CapableOf → cause infertility	0.24
estrogen → CapableOf → build up in the body	0.22
estrogen → IsA → powerful hormone	0.22
estrogen → CapableOf → cause depression	0.22
estrogen → ReceivesAction → stored in fat tissue	0.19
estrogen → CapableOf → increase the risk of dementia	0.19
estrogen → CapableOf → keep the skin	0.19
estrogen → HasSubevent → male gynecomastia	0.19
estrogen → HasProperty → proliferative	0.16
estrogen → CapableOf → form volatile hydroxyl radicals	0.16
estrogen → CapableOf → form associated dna damage	0.16
estrogen → CapableOf → form mutagenesis	0.16
estrogen → CapableOf → grow in the body	0.16
estrogen → CapableOf → leave the body	0.16
estrogen → ReceivesAction → linked to breast	0.16
estrogen → AtLocation → plastic	0.16
estrogen → CapableOf → affect the brain	0.16
estrogen → CapableOf → increase tbg concentrations	0.16
estrogen → CapableOf → prevent disease	0.16
estrogen → CapableOf → affect the breakdown of medications	0.16
estrogen → CapableOf → cause heart attacks	0.16
estrogen → CapableOf → become imbalanced	0.16
estrogen → CapableOf → cause uterine fibroids	0.16
estrogen → HasSubevent → male breast growth	0.16
estrogen → CapableOf → cause anxiety	0.16
estrogen → CapableOf → cause blood clots	0.16
synthetic estrogen (subgroup of estrogen) → ReceivesAction → used in birth control pills	0.16
effect (aspect of estrogen) → HasProperty → complex	0.16
effect (aspect of estrogen) → HasProperty → common	0.16
effect (aspect of estrogen) → ReceivesAction → noted	0.14
effect (aspect of estrogen) → ReceivesAction → reported	0.09