Assertion list
mutation (primary) → CapableOf
Results from Ascent++: 312
mutation → CapableOf → occur in exon 0.62
mutation → CapableOf → occur in codon 0.59
mutation → CapableOf → occur in gene 0.58
mutation → CapableOf → produce protein 0.58
mutation → CapableOf → change single protein building … 0.58
mutation → CapableOf → occur by chance 0.57
mutation → CapableOf → occur in fact 0.55
mutation → CapableOf → accumulate over time 0.54
mutation → CapableOf → drive carcinogenesis 0.54
mutation → CapableOf → enable mutant organism 0.54
mutation → CapableOf → encode protein 0.54
mutation → CapableOf → change amino acid 0.53
mutation → CapableOf → induce conformational change 0.53
mutation → CapableOf → occur at same site 0.52
mutation → CapableOf → occur in the dna 0.52
mutation → CapableOf → affect the gene 0.52
mutation → CapableOf → replace the amino acid arginine 0.52
mutation → CapableOf → affect splicing 0.52
mutation → CapableOf → occur 0.51
mutation → CapableOf → affect activity 0.51
mutation → CapableOf → occur in each generation 0.51
mutation → CapableOf → use quikchange site-directed mu… 0.51
mutation → CapableOf → affect the brain 0.50
mutation → CapableOf → replace the amino acid glycine 0.50
mutation → CapableOf → become fixed in population 0.50
mutation → CapableOf → occur in nature 0.49
mutation → CapableOf → increase in frequency 0.49
mutation → CapableOf → occur within gene 0.49
mutation → CapableOf → occur in region 0.49
mutation → CapableOf → affect embryogenesis 0.48
mutation → CapableOf → produce new alleles 0.48
mutation → CapableOf → increase the risk 0.48
mutation → CapableOf → occur after birth 0.48
mutation → CapableOf → occur in family 0.48
mutation → CapableOf → replace the amino acid leucine 0.48
mutation → CapableOf → destabilize the protein 0.47
mutation → CapableOf → affect the phenotype 0.46
mutation → CapableOf → affect gene expression 0.46
mutation → CapableOf → refer to change 0.46
mutation → CapableOf → change single dna building block 0.46
mutation → CapableOf → confer advantage 0.46
mutation → CapableOf → affect dna repair 0.46
mutation → CapableOf → occur in cell 0.45
mutation → CapableOf → activate the kinase 0.45
mutation → CapableOf → break gene 0.45
mutation → CapableOf → copy error 0.45
mutation → CapableOf → alter the amino acid sequence 0.45
mutation → CapableOf → change protein 0.45
mutation → CapableOf → become more common 0.45
mutation → CapableOf → occur at same time 0.44
mutation → CapableOf → occur for first time 0.43
mutation → CapableOf → use sanger sequencing 0.43
mutation → CapableOf → cause genetic disease 0.43
mutation → CapableOf → interact with each other 0.43
mutation → CapableOf → affect the structure 0.43
mutation → CapableOf → contribute to tumorigenesis 0.43
mutation → CapableOf → occur in sperm 0.43
mutation → CapableOf → replace the amino acid tyrosine 0.42
mutation → CapableOf → disrupt open reading frame 0.42
mutation → CapableOf → affect protein function 0.42
mutation → CapableOf → contribute to progression 0.42
mutation → CapableOf → predispose individual 0.42
mutation → CapableOf → confer selective advantage 0.41
mutation → CapableOf → spread through the population 0.41
mutation → CapableOf → harm the organism 0.41
mutation → CapableOf → disrupt oligomerization 0.41
mutation → CapableOf → reduce the strength 0.41
mutation → CapableOf → go undetected 0.41
mutation → CapableOf → go unnoticed 0.41
mutation → CapableOf → change single amino acids 0.41
mutation → CapableOf → produce new species 0.41
mutation → CapableOf → promote tumor growth 0.41
mutation → CapableOf → occur in hotspot,of a gene 0.41
mutation → CapableOf → enter the population 0.41
mutation → CapableOf → occur at steady rate 0.40
mutation → CapableOf → kill the organism 0.40
mutation → CapableOf → cause severe disease 0.40
mutation → CapableOf → report to date 0.40
mutation → CapableOf → reduce enzyme activity 0.39
mutation → CapableOf → support the notion 0.39
mutation → CapableOf → activate a cryptic splice donor… 0.39
mutation → CapableOf → confer a growth advantage 0.39
mutation → CapableOf → occur in individual 0.39
mutation → CapableOf → occur in somatic cells 0.39
mutation → CapableOf → affect only one allele 0.39
mutation → CapableOf → occur in kras 0.38
mutation → CapableOf → show incomplete penetrance 0.38
mutation → CapableOf → contribute to disease 0.38
mutation → CapableOf → affect transcription 0.38
mutation → CapableOf → set the stage 0.38
mutation → CapableOf → affect conserved residues 0.37
mutation → CapableOf → affect behavior 0.37
mutation → CapableOf → occur in egg 0.37
mutation → CapableOf → occur in intron 0.37
mutation → CapableOf → occur in the genome 0.37
mutation → CapableOf → confer proliferative advantage 0.36
mutation → CapableOf → increase life span 0.36
mutation → CapableOf → cause human disease 0.36
mutation → CapableOf → affect pathogenesis 0.35
mutation → CapableOf → affect protein stability 0.35
mutation → CapableOf → cause rare disease 0.35
mutation → CapableOf → occur in the germ cells 0.35
mutation → CapableOf → prevent phosphorylation 0.35
mutation → CapableOf → activate oncogene 0.35
mutation → CapableOf → create premature stop signal 0.35
mutation → CapableOf → occur in specific location 0.35
mutation → CapableOf → accumulate with age 0.34
mutation → CapableOf → affect mrna stability 0.34
mutation → CapableOf → change the length of the fragme… 0.34
mutation → CapableOf → do same thing 0.34
mutation → CapableOf → inactivate gene 0.34
mutation → CapableOf → use primer 0.34
mutation → CapableOf → affect cell size 0.34
mutation → CapableOf → increase cancer risk 0.34
mutation → CapableOf → occur in offspring 0.34
mutation → CapableOf → identify limb girdle muscular d… 0.33
mutation → CapableOf → originate in blood stem cells 0.33
mutation → CapableOf → predispose patient 0.33
mutation → CapableOf → increase chance 0.33
mutation → CapableOf → provide a survival advantage 0.33
mutation → CapableOf → confer antibiotic resistance 0.33
mutation → CapableOf → account for 80-90% of all lynch… 0.32
mutation → CapableOf → affect mrna splicing 0.32
mutation → CapableOf → affect single gene 0.32
mutation → CapableOf → affect the ribosome 0.32
mutation → CapableOf → arise in the middle east 0.32
mutation → CapableOf → confer protection 0.32
mutation → CapableOf → drive abnormal cell growth 0.32
mutation → CapableOf → encode neutrophil elastase 0.32
mutation → CapableOf → increase the rate 0.32
mutation → CapableOf → never been reported 0.32
mutation → CapableOf → occur at site 0.32
mutation → CapableOf → occur in mtdna 0.32
mutation → CapableOf → reduce binding affinity 0.32
mutation → CapableOf → run in the family 0.32
mutation → CapableOf → affect the heart 0.32
mutation → CapableOf → give edge 0.31
mutation → CapableOf → reduce the activity of the chan… 0.31
mutation → CapableOf → accumulate in the population 0.31
mutation → CapableOf → act as beacon 0.31
mutation → CapableOf → affect single dna nucleotide 0.31
mutation → CapableOf → change genetic code 0.31
mutation → CapableOf → delete genetic material 0.31
mutation → CapableOf → extend lifespan 0.31
mutation → CapableOf → occur at low frequency 0.31
mutation → CapableOf → occur in normal cells 0.31
mutation → CapableOf → produce similar phenotype 0.31
mutation → CapableOf → silence microrna 0.31
mutation → CapableOf → occur at high frequency 0.30
mutation → CapableOf → cause other disorders 0.30
mutation → CapableOf → form malignant tumors 0.30
mutation → CapableOf → raise the risk of breast cancer 0.30
mutation → CapableOf → affect viral replication 0.29
mutation → CapableOf → increase tobramycin sensitivity 0.29
mutation → CapableOf → insert genetic material 0.29
mutation → CapableOf → occur in gamete 0.29
mutation → CapableOf → occur in the area of the gene 0.29
mutation → CapableOf → prevent acetylation 0.29
mutation → CapableOf → range in size 0.29
mutation → CapableOf → replace the amino acid serine 0.29
mutation → CapableOf → accumulate in gene 0.29
mutation → CapableOf → affect the ability of the prote… 0.28
mutation → CapableOf → give a fitness advantage 0.28
mutation → CapableOf → prove fatal 0.28
mutation → CapableOf → occur in tumor suppressor genes 0.27
mutation → CapableOf → abrogate binding 0.27
mutation → CapableOf → affect catalytic activity 0.27
mutation → CapableOf → affect folding 0.27
mutation → CapableOf → affect patterning 0.27
mutation → CapableOf → affect protein-protein interact… 0.27
mutation → CapableOf → alter a gene's dna base sequence 0.27
mutation → CapableOf → be a fact of life 0.27
mutation → CapableOf → cause other neuromuscular disea… 0.27
mutation → CapableOf → change the shape of a protein 0.27
mutation → CapableOf → encode a wnt protein 0.27
mutation → CapableOf → encode intracellular part 0.27
mutation → CapableOf → impact the dna 0.27
mutation → CapableOf → inactivate p53 0.27
mutation → CapableOf → lighten the skin 0.27
mutation → CapableOf → occur in reproductive cells 0.27
mutation → CapableOf → occur in the nthl1 gene 0.27
mutation → CapableOf → promote tissue healing 0.27
mutation → CapableOf → protect against malaria 0.27
mutation → CapableOf → replace amino acid aspartic acid 0.27
mutation → CapableOf → replace functional version of t… 0.27
mutation → CapableOf → underlie common familial exudat… 0.27
mutation → CapableOf → use next-generation sequencing 0.27
mutation → CapableOf → use oligonucleotide 0.27
mutation → CapableOf → occur in coding region 0.26
mutation → CapableOf → be a risk factor 0.26
mutation → CapableOf → drive aggressive disease progre… 0.26
mutation → CapableOf → account for 90% of cases 0.25
mutation → CapableOf → activate ras 0.25
mutation → CapableOf → add genetic information 0.25
mutation → CapableOf → affect diverse cardiac developm… 0.25
mutation → CapableOf → affect gene activity levels 0.25
mutation → CapableOf → affect homologous recombination 0.25
mutation → CapableOf → affect isoform 0.25
mutation → CapableOf → affect locomotion 0.25
mutation → CapableOf → affect mirna function 0.25
mutation → CapableOf → affect morphology 0.25
mutation → CapableOf → affect pigmentation 0.25
mutation → CapableOf → affect specificity of gene acti… 0.25
mutation → CapableOf → affect srsf2 0.25
mutation → CapableOf → affect the globule 0.25
mutation → CapableOf → affect the stability of rt 0.25
mutation → CapableOf → affect trait 0.25
mutation → CapableOf → affect viability 0.25
mutation → CapableOf → arise in africa 0.25
mutation → CapableOf → call antennapedia 0.25
mutation → CapableOf → cause monogenic disease 0.25
mutation → CapableOf → change the code 0.25
mutation → CapableOf → change the level of metabolic c… 0.25
mutation → CapableOf → confer defect 0.25
mutation → CapableOf → contribute to chronic hbv infec… 0.25
mutation → CapableOf → contribute to disease initiation 0.25
mutation → CapableOf → counter the loss of genetic mat… 0.25
mutation → CapableOf → create new genes 0.25
mutation → CapableOf → define 21-day biological clock 0.25
mutation → CapableOf → define distinct clinical phenot… 0.25
mutation → CapableOf → delete small amounts of dna 0.25
mutation → CapableOf → destabilize optimal solution 0.25
mutation → CapableOf → destabilize the complex 0.25
mutation → CapableOf → differentiate the two haplotypes 0.25
mutation → CapableOf → drive pediatric glioblastoma 0.25
mutation → CapableOf → encode a-type lamins 0.25
mutation → CapableOf → encode alpha-actinin-4 0.25
mutation → CapableOf → encode cu/zn superoxide dismuta… 0.25
mutation → CapableOf → encode dna gyrase 0.25
mutation → CapableOf → encode α-synuclein 0.25
mutation → CapableOf → enhance the function of apob 0.25
mutation → CapableOf → fall into three categories 0.25
mutation → CapableOf → help explain high virulence of … 0.25
mutation → CapableOf → help identify therapeutic targe… 0.25
mutation → CapableOf → identify a ct transition 0.25
mutation → CapableOf → impair hematopoietic differenti… 0.25
mutation → CapableOf → impair lysosomal function 0.25
mutation → CapableOf → impair nhej 0.25
mutation → CapableOf → increase genetic variation 0.25
mutation → CapableOf → induce bursting of sensory neur… 0.25
mutation → CapableOf → influence the clarity of the ti… 0.25
mutation → CapableOf → involve rearrangement 0.25
mutation → CapableOf → lymphomagenesis in a subset of … 0.25
mutation → CapableOf → occur after fertilization 0.25
mutation → CapableOf → occur at any time 0.25
mutation → CapableOf → occur at rate 0.25
mutation → CapableOf → occur in cat 0.25
mutation → CapableOf → occur in dog 0.25
mutation → CapableOf → occur in domain 0.25
mutation → CapableOf → occur in first place 0.25
mutation → CapableOf → occur in maffucci syndrome 0.25
mutation → CapableOf → occur in melanocyte 0.25
mutation → CapableOf → occur in microsatellite 0.25
mutation → CapableOf → played important role 0.25
mutation → CapableOf → predispose to ndd 0.25
mutation → CapableOf → produce mutant androgen recepto… 0.25
mutation → CapableOf → push the cell cycle 0.25
mutation → CapableOf → reduce viral infectivity 0.25
mutation → CapableOf → replace the amino acid proline 0.25
mutation → CapableOf → replace the nucleotide guanine 0.25
mutation → CapableOf → screen in certain populations 0.25
mutation → CapableOf → sensitize cell 0.25
mutation → CapableOf → show significant association 0.25
mutation → CapableOf → spread throughout eurasia 0.25
mutation → CapableOf → stop at the himalayas 0.25
mutation → CapableOf → test for patient 0.25
mutation → CapableOf → theprocess of tumorgenesis 0.25
mutation → CapableOf → transfected into suitable expre… 0.25
mutation → CapableOf → use ngs 0.25
mutation → CapableOf → winnow the list of candidate ge… 0.25
mutation → CapableOf → encode tdp-43 0.25
mutation → CapableOf → oxidative stress 0.25
mutation → CapableOf → affect transcriptional activati… 0.24
mutation → CapableOf → alter the product of a gene 0.24
mutation → CapableOf → interfere with signal 0.24
mutation → CapableOf → damage gene 0.22
mutation → CapableOf → drive treatment resistance 0.22
mutation → CapableOf → emerge in the egfr gene 0.22
mutation → CapableOf → produce viable homozygous anima… 0.22
mutation → CapableOf → never adds any information 0.21
mutation → CapableOf → wreak havoc 0.21
mutation → CapableOf → affect virulence 0.20
mutation → CapableOf → occur in female 0.19
mutation → CapableOf → turn cancerous 0.19
mutation → CapableOf → alter reading frame of the gene 0.19
mutation → CapableOf → encode atp-binding cassette tra… 0.19
mutation → CapableOf → give protein new toxic properti… 0.19
mutation → CapableOf → knock down gene function 0.19
mutation → CapableOf → lie dormant 0.19
mutation → CapableOf → occur under cellular control 0.19
mutation → CapableOf → turn off the gene 0.19
mutation → CapableOf → affect flowering time 0.18
mutation → CapableOf → provide opportunity 0.18
mutation → CapableOf → affect the ability of cells 0.16
mutation → CapableOf → behave as gatekeeper 0.16
mutation → CapableOf → confer predictable fitness impr… 0.16
mutation → CapableOf → cripple the repair process 0.16
mutation → CapableOf → destabilize the tetramer 0.16
mutation → CapableOf → disrupt dimer formation 0.16
mutation → CapableOf → disrupt dystroglycan o-mannosyl… 0.16
mutation → CapableOf → encode a 3beta-hydroxysteroid d… 0.16
mutation → CapableOf → encode ligand 0.16
mutation → CapableOf → induce aberrant splicing 0.16
mutation → CapableOf → leave the body 0.16
mutation → CapableOf → occur in protooncogene 0.16
mutation → CapableOf → prevent red blood cells 0.16
mutation → CapableOf → suppress immune system 0.16
mutation → CapableOf → survive in the wild 0.16
mutation → CapableOf → think to promote deep lung infe… 0.16
mutation → CapableOf → undergo endocytosis 0.16
mutation → CapableOf → occur on transmembrane 0.16
mutation → CapableOf → occur in sequence 0.09