mutation primary subject, 1000 assertions
Subgroups 6
somatic mutation 10
beneficial mutation 7
new mutation 5
frameshift mutation 4
genetic variation 2
spontaneous mutation 1
Aspects 2
effect 124
power 9
AtLocation 53
patient 0.63
tumor 0.56
cancer 0.56
people 0.56
melanoma 0.55
child 0.54
combination 0.51
single family 0.50
primary tumor 0.48
cancer cells 0.48
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CapableOf 312
occur in exon 0.62
occur in codon 0.59
occur in gene 0.58
produce protein 0.58
change single protein b… 0.58
occur by chance 0.57
occur in fact 0.55
accumulate over time 0.54
drive carcinogenesis 0.54
enable mutant organism 0.54
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Causes 122
reduction 0.65
disease 0.62
cystic fibrosis 0.59
frameshift 0.55
a loss of information 0.49
loss of function 0.48
rp 0.48
condition 0.46
syndrome 0.44
mo 0.44
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CreatedBy 1
crispr 0.25
HasA 20
little effect 0.63
effect 0.62
same effect 0.59
minor effect 0.58
significant effect 0.55
impact 0.55
profound effects 0.51
consequence 0.50
deleterious effects 0.49
negative effect 0.46
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HasProperty 101
random 0.77
neutral 0.74
rare 0.73
harmful 0.69
heterozygous 0.68
common 0.66
novel 0.65
somatic 0.64
deleterious 0.64
beneficial 0.64
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HasSubevent 75
cancer 0.63
amino acid substitutions 0.57
amino acid changes 0.55
cancer development 0.53
evolution 0.53
a premature stop codon 0.51
increase 0.51
shift 0.50
premature stop 0.50
genomic instability 0.49
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IsA 5
change 0.72
permanent change 0.61
sudden change 0.29
single base changes 0.25
a base-pair sequence ch… 0.25
MadeOf 2
certainty 0.25
clinical applications o… 0.25
ReceivesAction 308
inherited 0.66
shown in table 0.66
associated with resista… 0.66
confirmed 0.63
selected 0.63
confirmed by dna sequen… 0.62
confirmed by sanger seq… 0.61
associated with disease 0.61
tested 0.61
favored by natural sele… 0.59
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RelatedTo 1
occult infection 0.25