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melatonin → IsA → hormone	0.81
melatonin → ReceivesAction → produced by pineal gland	0.74
melatonin → ReceivesAction → secreted by pineal gland	0.68
hormone melatonin (subgroup of melatonin) → ReceivesAction → secreted by pineal gland	0.68
natural melatonin (subgroup of melatonin) → ReceivesAction → made from pineal gland of animals	0.68
role (aspect of melatonin) → HasProperty → critical	0.68
tart cherry (subgroup of cherry) → HasA → melatonin	0.68
melatonin → ReceivesAction → released	0.67
melatonin → ReceivesAction → produced by the body	0.66
benefit (aspect of melatonin) → ReceivesAction → derived	0.65
melatonin → ReceivesAction → produced	0.64
melatonin → ReceivesAction → produced in the brain	0.62
melatonin → ReceivesAction → secreted	0.60
prolonged release melatonin (subgroup of melatonin) → HasProperty → safe	0.59
supplemental melatonin (subgroup of melatonin) → HasProperty → helpful	0.59
melatonin → HasProperty → safe	0.59
cherry → HasA → melatonin	0.58
effect (aspect of melatonin) → HasProperty → mild	0.58
melatonin → CapableOf → promote sleep	0.54
melatonin → HasProperty → effective	0.54
melatonin → IsA → natural hormone	0.54
melatonin → ReceivesAction → synthesized	0.54
melatonin → ReceivesAction → taken at night	0.54
melatonin → ReceivesAction → produced at night	0.54
effect (aspect of melatonin) → HasProperty → rare	0.52
effect (aspect of melatonin) → HasProperty → minimal	0.52
melatonin → CapableOf → regulate sleep	0.52
melatonin → CapableOf → wake cycle	0.52
melatonin → ReceivesAction → taken before bedtime	0.51
melatonin → ReceivesAction → taken as supplement	0.51
melatonin → IsA → the sleep hormone	0.51
melatonin → HasProperty → important	0.50
melatonin → CapableOf → regulate circadian rhythm	0.50
melatonin → ReceivesAction → taken by mouth	0.50
melatonin → HasProperty → beneficial	0.50
melatonin → ReceivesAction → used as a sleep aid	0.50
effect (aspect of melatonin) → ReceivesAction → investigated	0.49
effect (aspect of melatonin) → HasProperty → unknown	0.49
melatonin → ReceivesAction → sold over the counter	0.49
melatonin → IsA → occurring hormone	0.49
melatonin → ReceivesAction → linked	0.48
melatonin → ReceivesAction → used to treat insomnia	0.48
melatonin → CapableOf → regulate sleep/wake cycles	0.48
melatonin → ReceivesAction → sold as dietary supplement	0.48
melatonin → HasA → effect	0.47
melatonin → CapableOf → induce sleepiness	0.46
melatonin → IsA → important hormone	0.46
melatonin → HasProperty → helpful	0.46
effect (aspect of melatonin) → HasProperty → short-lived	0.46
effect (aspect of melatonin) → HasProperty → psychological	0.46
melatonin → HasProperty → natural	0.46
melatonin → ReceivesAction → increased	0.46
melatonin → ReceivesAction → released into the blood	0.45
melatonin → AtLocation → animal	0.45
melatonin → CapableOf → regulate sleep cycles	0.43
melatonin → CapableOf → help with jet lag	0.43
melatonin → CapableOf → fall asleep	0.43
melatonin → CapableOf → help people	0.42
melatonin → CapableOf → protect cell	0.42
melatonin → HasProperty → low	0.42
melatonin → AtLocation → plant	0.42
effect (aspect of melatonin) → ReceivesAction → reported	0.42
effect (aspect of melatonin) → HasProperty → more pronounced	0.42
effect (aspect of melatonin) → HasProperty → significant	0.42
melatonin → CapableOf → occur in the body	0.42
walnut → HasA → melatonin	0.42
melatonin → CapableOf → signal the body	0.41
melatonin → CapableOf → treat intervertebral disc degeneration	0.41
melatonin → ReceivesAction → suppressed	0.41
melatonin → CapableOf → improve sleep quality	0.40
melatonin → CapableOf → reduce oxidative stress	0.40
melatonin → CapableOf → act as antioxidant	0.40
melatonin → CapableOf → regulate body's internal clock	0.40
melatonin → HasProperty → high	0.40
melatonin → HasProperty → powerful	0.40
melatonin → ReceivesAction → involved in sleep	0.39
melatonin → ReceivesAction → affected by light	0.39
melatonin → CapableOf → regulate mood	0.39
melatonin → HasProperty → key	0.39
melatonin → CapableOf → support normal immune function	0.39
melatonin → CapableOf → interact with other drugs	0.39
melatonin → CapableOf → improve sleep	0.39
melatonin → ReceivesAction → taken by people	0.39
melatonin → CapableOf → lower blood pressure	0.38
melatonin → ReceivesAction → stimulated by darkness	0.38
melatonin → ReceivesAction → secreted at night	0.38
melatonin → ReceivesAction → derived	0.38
melatonin → CapableOf → lower body temperature	0.38
melatonin → ReceivesAction → studied	0.38
melatonin → ReceivesAction → recommended	0.38
melatonin → CapableOf → inhibit tumor growth	0.37
melatonin → MadeOf → serotonin	0.37
melatonin → IsA → powerful hormone	0.37
melatonin → IsA → neurotransmitter	0.37
melatonin → ReceivesAction → absorbed	0.37
melatonin → AtLocation → microbe	0.37
melatonin → MadeOf → the amino acid tryptophan	0.37
melatonin → AtLocation → food	0.37
melatonin → CapableOf → occur in small amounts	0.37
melatonin → ReceivesAction → cleared	0.37
melatonin → CapableOf → affect sleep	0.36
melatonin → CapableOf → improve duration	0.36
effect (aspect of melatonin) → HasProperty → strong	0.35
melatonin → Causes → drowsiness	0.35
melatonin → IsA → pineal hormone	0.35
melatonin → HasProperty → right	0.35
melatonin → CapableOf → regulate sleep patterns	0.35
melatonin → CapableOf → permeate any cell	0.35
melatonin → CapableOf → reduce sleep onset latency	0.35
melatonin → Causes → change	0.35
melatonin → HasA → protective effects	0.34
melatonin → IsA → vital neuroendocrine hormone	0.34
melatonin → CapableOf → increase glutathione peroxidase	0.34
melatonin → HasProperty → neuroprotective	0.34
melatonin → AtLocation → tomato	0.34
melatonin → CapableOf → suppress the development of breast cancer	0.34
effect (aspect of melatonin) → HasProperty → gastrointestinal	0.34
melatonin → CapableOf → shift work	0.33
melatonin → HasA → property	0.33
melatonin → CapableOf → help regulate other hormones	0.33
melatonin → AtLocation → cherry	0.33
melatonin → ReceivesAction → taken in the morning	0.33
melatonin → HasProperty → active	0.33
melatonin → HasProperty → synthetic	0.33
effect (aspect of melatonin) → HasProperty → immediate	0.33
milk → HasA → melatonin	0.33
melatonin → CapableOf → cross the blood-brain barrier	0.32
melatonin → IsA → drug	0.32
melatonin → CapableOf → maintain nucleus pulposus cells	0.32
melatonin → AtLocation → banana	0.32
melatonin → CapableOf → increase the risk	0.32
melatonin → CapableOf → regulate the onset of puberty	0.32
melatonin → CapableOf → bind to receptor	0.32
melatonin → CapableOf → minimize myocardial injury	0.32
melatonin → CapableOf → slow aging process	0.32
melatonin → CapableOf → help protect the body	0.32
sweet cherry (subgroup of cherry) → HasA → melatonin	0.32
melatonin → CapableOf → reduce body weight gain	0.31
melatonin → ReceivesAction → purchased without prescription	0.31
melatonin → ReceivesAction → produced by small gland	0.31
melatonin → HasProperty → soluble	0.31
melatonin → ReceivesAction → reduced	0.31
melatonin → HasA → opposite effect	0.31
melatonin → CapableOf → inhibit the release of estrogen	0.31
melatonin → ReceivesAction → used in conjunction	0.31
melatonin → CapableOf → promote a more restful	0.31
melatonin → CapableOf → scavenge free radicals	0.31
melatonin → Causes → headache	0.31
effect (aspect of melatonin) → HasProperty → beneficial	0.30
melatonin → HasA → an anticancer effect	0.30
melatonin → ReceivesAction → compared to placebo	0.30
melatonin → AtLocation → fungus	0.30
melatonin → HasProperty → addictive	0.30
melatonin → ReceivesAction → used with caution	0.30
melatonin → CapableOf → inhibit proliferation	0.30
melatonin → CapableOf → protect lipid	0.30
melatonin → CapableOf → promote agent	0.30
melatonin → AtLocation → nut	0.30
melatonin → CapableOf → bypass the liver	0.30
melatonin → CapableOf → regulate glucose metabolism	0.30
melatonin → ReceivesAction → shown to stimulate silymarin	0.30
melatonin → CapableOf → get for some people	0.30
melatonin → CapableOf → neutralize free radicals	0.30
melatonin → CapableOf → prevent cancer	0.30
melatonin → Causes → depression	0.30
melatonin → CapableOf → cross cell membranes	0.30
effect (aspect of melatonin) → HasProperty → lasting	0.29
effect (aspect of melatonin) → ReceivesAction → felt	0.29
melatonin → CapableOf → help child	0.29
melatonin → ReceivesAction → prescribed	0.29
melatonin → ReceivesAction → purchased	0.29
melatonin → CapableOf → inhibit angiogenesis	0.29
melatonin → CapableOf → promote bone formation	0.29
benefit (aspect of melatonin) → ReceivesAction → seen in insomniac	0.29
melatonin → CapableOf → improve total sleep time	0.29
melatonin → CapableOf → offer analgesic effect	0.29
melatonin → Causes → dizziness	0.29
melatonin → ReceivesAction → taken in dose	0.28
melatonin → ReceivesAction → used to treat jet	0.28
melatonin → CapableOf → reduce anxiety	0.28
melatonin → HasProperty → anti-oxidant	0.28
melatonin → HasProperty → more effective than glutathione	0.28
melatonin → HasA → side effects	0.28
melatonin → CapableOf → decline with age	0.28
melatonin → HasProperty → anti	0.28
melatonin → CapableOf → offer pain relieving effect	0.28
drink → HasA → melatonin	0.27
melatonin → CapableOf → relax sleep	0.27
melatonin → CapableOf → increase the speed	0.27
melatonin → ReceivesAction → tolerated	0.27
melatonin → HasProperty → dangerous	0.27
melatonin → CapableOf → increase superoxide dismutase	0.27
melatonin → CapableOf → increase the risk of seizures	0.27
melatonin → ReceivesAction → combined with vincristine	0.27
melatonin → AtLocation → grape	0.27
melatonin → ReceivesAction → released in the evening	0.27
melatonin → HasProperty → identical	0.27
melatonin → CapableOf → help control release	0.27
melatonin → ReceivesAction → produced in the retina	0.27
melatonin → CapableOf → improve abdominal pain	0.27
melatonin → HasProperty → harmless	0.27
melatonin → CapableOf → suppress multiplication	0.27
melatonin → CapableOf → facilitate cued fear extinction	0.27
melatonin → ReceivesAction → metabolised	0.27
effect (aspect of melatonin) → HasProperty → common	0.27
effect (aspect of melatonin) → HasProperty → stronger	0.27
melatonin → Causes → relaxation	0.27
melatonin → ReceivesAction → important for protecting cellular dna	0.26
melatonin → Causes → nausea	0.26
melatonin → HasProperty → unsafe	0.25
melatonin → ReceivesAction → avoided	0.25
melatonin → HasA → calming effect	0.25
melatonin → CapableOf → support healthy immune and stress response	0.25
melatonin → CapableOf → interfere with ovulation	0.25
melatonin → ReceivesAction → released into third ventricle	0.25
melatonin → HasA → a particle size distribution profile	0.25
melatonin → ReceivesAction → synthesized in gastrointestinal tract	0.25
melatonin → CapableOf → protect spermatogonia	0.25
melatonin → CapableOf → lower the period	0.25
melatonin → CapableOf → reduce prostate cancer cell growth	0.25
melatonin → CapableOf → exert oncostatic effects	0.25
melatonin → ReceivesAction → released into cerebrospinal fluid	0.25
melatonin → CapableOf → pass into breast milk	0.25
melatonin → ReceivesAction → delayed	0.25
melatonin → HasA → fewer hours of daylight	0.25
melatonin → AtLocation → barley	0.25
melatonin → ReceivesAction → available in tablet	0.25
melatonin → AtLocation → oats	0.25
melatonin → ReceivesAction → discovered in 1995	0.25
melatonin → CapableOf → interact with birth control pills	0.25
melatonin → ReceivesAction → carried by the circulation system	0.25
melatonin → CapableOf → reduce lipid peroxidation	0.25
melatonin → CapableOf → reduce nerve activity	0.25
melatonin → CapableOf → exhibit growth-inhibitory effect	0.25
melatonin → CapableOf → help control waking	0.25
melatonin → CapableOf → cross the placenta	0.25
melatonin → ReceivesAction → classified as dietary supplement	0.25
melatonin → ReceivesAction → involved in energy metabolism	0.25
melatonin → ReceivesAction → stopped	0.25
melatonin → CapableOf → maintain adult hippocampal neurogenesis	0.25
melatonin → CapableOf → maintain cognitive functions	0.25
melatonin → ReceivesAction → studied for delayed sleep phase syndrome	0.25
melatonin → CapableOf → stay high	0.25
melatonin → ReceivesAction → shown to stimulate related enzyme	0.25
melatonin → Causes → vivid dreams	0.25
melatonin → ReceivesAction → used to treat seasonal affective disorder	0.25
melatonin → CapableOf → decrease brain edema	0.25
melatonin → IsA → biogenic amine	0.25
melatonin → CapableOf → delay rhythm	0.25
synthetic melatonin (subgroup of melatonin) → HasProperty → identical	0.25
benefit (aspect of melatonin) → CapableOf → outweigh risk	0.25
effect (aspect of melatonin) → CapableOf → remain controversial	0.25
effect (aspect of melatonin) → ReceivesAction → associated with proton pump inhibitors	0.25
effect (aspect of melatonin) → CapableOf → vary to person	0.25
effect (aspect of melatonin) → HasProperty → reversible	0.25
effect (aspect of melatonin) → ReceivesAction → reduced	0.25
role (aspect of melatonin) → ReceivesAction → established	0.25
role (aspect of melatonin) → HasProperty → controversial	0.25
melatonin → HasProperty → superior	0.24
melatonin → Causes → irritability	0.24
melatonin → CapableOf → prevent cell damage	0.24
melatonin → HasA → few side effects	0.24
melatonin → CapableOf → decrease inflammation	0.24
melatonin → CapableOf → help dog	0.23
melatonin → CapableOf → become popular	0.23
melatonin → ReceivesAction → available in cream	0.23
melatonin → Causes → fatigue	0.23
melatonin → CapableOf → show promise	0.23
melatonin → ReceivesAction → associated with significant decrease	0.23
melatonin → CapableOf → calm down nervous system irritability	0.23
melatonin → ReceivesAction → shown in study	0.23
melatonin → HasProperty → inexpensive	0.23
effect (aspect of melatonin) → ReceivesAction → noted	0.22
melatonin → CapableOf → induce apoptosis	0.21
melatonin → HasProperty → more effective than placebo	0.21
melatonin → HasA → good safety profile	0.21
melatonin → CapableOf → produce grogginess	0.21
melatonin → CapableOf → support cardiovascular health	0.21
melatonin → CapableOf → promote longevity	0.21
melatonin → ReceivesAction → taken at appropriate time	0.21
effect (aspect of melatonin) → HasProperty → cumulative	0.21
melatonin → HasProperty → deficient	0.20
melatonin → HasA → metal binding role	0.20
melatonin → CapableOf → facilitate the removal of toxic metals	0.20
effect (aspect of melatonin) → HasProperty → noticeable	0.20
effect (aspect of melatonin) → ReceivesAction → observed	0.19
banana → HasA → melatonin	0.19
melatonin → CapableOf → act as immunomodulator	0.18
melatonin → ReceivesAction → supported by scientific research	0.18
melatonin → CapableOf → prevent memory loss	0.18
melatonin → CapableOf → suppress ultraviolet	0.18
melatonin → CapableOf → stretch hard and fast rest time	0.18
melatonin → CapableOf → diminish the seriousness of retinopathy	0.18
melatonin → CapableOf → start on the day of travel	0.18
melatonin → CapableOf → oppose each other	0.18
melatonin → CapableOf → support the endocrine system	0.18
melatonin → CapableOf → provide anxiolysis	0.18
melatonin → CapableOf → decrease intraocular pressure	0.18
melatonin → CapableOf → promote better operating conditions	0.18
melatonin → CapableOf → protect the heart	0.16
melatonin → ReceivesAction → responsible for restoration	0.16
melatonin → CapableOf → increase blood sugar	0.16
melatonin → CapableOf → potentiate the effects of gamma-aminobutyric acid	0.16
melatonin → CapableOf → improve bowel symptoms	0.16
melatonin → Causes → insulin resistance	0.16
melatonin → CapableOf → improve egg quality	0.16
melatonin → ReceivesAction → taken for short periods of time	0.16
melatonin → CapableOf → improve concentration	0.16
melatonin → ReceivesAction → produced in the winter	0.16
melatonin → CapableOf → decrease the effectiveness of diabetes medications	0.16
melatonin → CapableOf → improve quantity	0.16
melatonin → CapableOf → relieve depression	0.16
melatonin → CapableOf → continue helps for several days	0.16
melatonin → ReceivesAction → overused	0.16
melatonin → CapableOf → work in harmony	0.16
melatonin → CapableOf → treat heartburn	0.16
melatonin → ReceivesAction → believed to be the most lipophilic antioxidant	0.16
effect (aspect of melatonin) → ReceivesAction → documented	0.16
effect (aspect of melatonin) → HasProperty → serious	0.16
effect (aspect of melatonin) → ReceivesAction → increased	0.16
function (aspect of melatonin) → ReceivesAction → impaired	0.16